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Drug Labels & Clinical Guidelines

Below is a  table adapted  from the U.S. Food and Drug Administration’s  Pharmacogenomic Biomarkers in Drug Labels All drugs listed below include PGx information in their drug labels. We have included the drug name, the associated PGx Biomarker, and a link to professional positional statements and clinical guidelines.

Alecensa®(Alectinib)ALKNo clinical guidelines available.Praluent®(Alirocumab)LDLRNo clinical guidelines available.Brovana®(Arformoterol)UGT1A1, CYP2D6No clinical guidelines available.Aristada®(Aripiprazole Lauroxil)CYP2D6No clinical guidelines available.

Brand Name (alphabetized by Generic Name) Biomarker Professional Position Statements & Clinical Guidelines
Ziagen®(Abacavir) HLA-B*5701 CPIC Guidelines (2014) HIV Medicine Association of the Infectious Diseases Society of America (2009) 
Kadcyla®(Ado-Trastuzumab Emtansine) ERBB2 No clinical guidelines available.
Gilotrif®(Afatinib) EGFR No clinical guidelines available.
Elavil®(Amitriptyline) CYP2D6 CPIC Guidelines (2013)
Arimidex®(Anastrozole) ESR1, PGR No clinical guidelines available.
Abilify®(Aripiprazole) CYP2D6 No clinical guidelines available.
Brovana®(Arformoterol) UGT1A1, CYP2D6 No clinical guidelines available.
Trisenox®(Arsenic Trioxide) PML/RARα No clinical guidelines available.
Strattera®(Atomoxetine) CYP2D6 No clinical guidelines available.
Imuran®(Azathioprine) TPMT CPIC Guidelines (2013)
Beleodaq®(Belinostate) UGT1A1 No clinical guidelines available.
Blincyto®(Blinatumomab) BRC-ABL1 No clinical guidelines available.
Victrelis®(Boceprevir) IL28B Dept of Veterans Affairs Hep C Resource Center Program & the National Hep C Program Office
CPIC Guidelines (2031)
Bosulif®(Bosutinib) BCR-ABL1 No clinical guidelines available.
Rexulti®(Brexpiprazole) CYP2D6 No clinical guidelines available.
Busulfex®(Busulfan) Ph Chromosome No clinical guidelines available.
Cabometyx®; Cometriq®(Cabozantinib) RET No clinical guidelines available.
Xeloda®(Capecitabine) DPD CPIC Guidelines (2013)
Tegretol®(Carbamazepine) HLA-B*1502 HLA-A*3101 CPIC Guidelines (2013)
Carbaglu®(Carglumic Acid) NAGS No clinical guidelines available
Soma®(Carisoprodol) CYP2C19 No clinical guidelines available.
Coreg®(Carvedilol) CYP2D6 No clinical guidelines available.
Celebrex®(Celecoxib) CYP2C9 No clinical guidelines available.
Zykadia®(Ceritinib) ALK No clinical guidelines available.
Erbitux®(Cetuximab) EGFR, KRAS National Comprehensive Cancer Network (2014)
Evoxac®(Cevimeline) CYP2D6 No clinical guidelines available.
Aralen®(Chloroquine) G6PD No clinical guidelines available.
Diabinese®(Chlorpropamide) G6PD No clinical guidelines available.
Cholbam®(Cholic Acid) AKR1D1, HSD3B7, CYP27A1, AMACR, CYP7A1 No clinical guidelines available.
Platinol®(Cisplatin) TPMT No clinical guidelines available
Celexa®(Citalopram) CYP219, CYPD6 CPIC Guidelines (2015)
Onfi®(Clobazam) CYP2C19 No clinical guidelines available.
Anafranil®(Clomipramine) CYPD2D6 CPIC Guidelines (2013)
Plavix® (Clopidogrel) CYP2C19 CPIC Guidelines (2013)American College of Cardiology Foundation/American Heart Association (2012)

American College of Cardiology Foundation (2011)

Clozaril®(Clozapine) CYP2D6 No clinical guidelines available.
Cotellic®(Cobimetinib) BRAF No clinical guidelines available.
Codeine® (Codeine) CYP2D6 CPIC Guidelines (2014)
Xalkori®(Crizotinib) ALK No clinical guidelines available.
Tafinlar®(Dabrafenib) BRAF
G6PD
No clinical guidelines available.
Aczone®(Dapsone) G6PD No clinical guidelines available.
Sprycel®(Dasatinib) Ph Chromosome No clinical guidelines available.
Ontak®(Denileukin Diftitox) IL2RA No clinical guidelines available.
Norpramin®(Desipramine) CPY2D6 CPIC Guidelines (2013)
Dexilant® (Dexlansoprazole) CYP2C19
CYP1A2
No clinical guidelines available.
Nuedexta®(Dextromethorphan and Quinidine) CYP2D6 No clinical guidelines available.
Valium® (Diazepam) CYP2C19 No clinical guidelines available.
Unituxin®(Dinutuximab) MYCN No clinical guidelines available.
Tivicay®(Dolutegravir) UGT1A1 No clinical guidelines available.
Silenor®(Doxepin) CYP2D6 CPIC Guidelines (2013)
Yaz® (Drospirenone and Ethinly Estradiol) CYP2C19 No clinical guidelines available.
Cerdelga® (Eliglustat) CYP2D6 No clinical guidelines available.
Cimizim®(Elosulfase) GALNS No clinical guidelines available.
Promacta®(Eltrombopag) 5F, SERPINC1 No clinical guidelines available.
Tarceva®(Erlotinib) EGFR No clinical guidelines available.
Lexapro®(Escitalopram) CYP2D6, CYP2C19 CPIC Guidelines (2015)
Nexium® (Esomeprazole) CYP2C19 No clinical guidelines available.
Afinitor®(Everolimus) ERBB2, ESR1 No clinical guidelines available.
Repatha®(Evolocumab) LDLR No clinical guidelines available.
Aromasin®(Exemestane) ESR1, PGR No clinical guidelines available.
Toviaz®(Fesoterodine) CYP2D6 No clinical guidelines available.
Carac®; Efudex®; Fluoroplex®(Fluorouracil) DPYD CPIC Guidelines (2013)
Prozac®(Fluoxetine) CYP2D6 No clinical guidelines available.
Ansaid® (Flurbiprofen) CYP2C9 No clinical guidelines available.
Luvox® CR(Fluvoxamine) CYP2D6 CPIC Guidelines (2015)
Faslodex®(Fulvestrant) ER receptor No clinical guidelines available.
Razadyne®(Galantamine) CYP2D6 No clinical guidelines available.
Iressa®(Gefitib) EFGR No clinical guidelines available.
Amaryl®(Glimepiride) G6PD No clinical guidelines available.
Glucotrol®(Glipizide) G6PD No clinical guidelines available.
Amaryl®(Glimepiride) G6PD No clinical guidelines available.
Apresoline®(Hydralazine) NAT1-2 No clinical guidelines available.
Glucotrol®(Glipizide) G6PD No clinical guidelines available.
Diabeta®
Glynase®(Glyburide)
G6PD No clinical guidelines available.
Imbruvica®(Ibrutinib) del (17p) No clinical guidelines available.
Fanapt®(Iloperidone) CYP2D6 No clinical guidelines available.
Gleevec®(Imatinib) C-Kit, Ph Chromosome, PDGFR,FIP1L1-PDGFRα No clinical guidelines available.
Tofranil® (Imipramine) CYP2D6 CPIC Guidelines (2013)
Arcapta® Neohaler®(Indacaterol) UGT1A1 No clinical guidelines available.
Camptosar®(Irinotecan) UGT1A1 No clinical guidelines available.
Kalydeco®(Ivacaftor) CFTR (G551D) CPIC Guidelines (2014)
Vimpat®(Lacosamide) CYP2C19 No clinical guidelines available.
Prevacid®(Lansoprazole) CYP2C19 No clinical guidelines available.
Tykerb®(Lapatinib) HER2/neu No clinical guidelines available.
Revlimid®(Lenalidomide) Chromosome 5q No clinical guidelines available.
Zurmpic®(Lesinurad) CYP2C9 No clinical guidelines available.
Femara®(letrozole) ER&PgR receptor No clinical guidelines available.
Juxtapid®(Lomitapide) LDLR No clinical guidelines available.
Orkambi®(Ivacaftor and Lumacaftor) CFTR No clinical guidelines available.
Sulfamylon®(Mafenide) G6PD No clinical guidelines available.
Purinethol®(Mercaptopurine) TPMT CPIC Guidelines (2013)
Methylene Blue(Methylene Blue) G6PD No clinical guidelines available.
Reglan®(Metoclopramide) CYB5R1-4, G6PD No clinical guidelines available.
Lopressor®(Metoprolol) CYP2D6 No clinical guidelines available.
Kynamro®(Mipomersen) LDLR No clinical guidelines available.
Provigil®(Modafinil) CYP2D6 No clinical guidelines available.
Myfortic®(Mycophenolic Acid) HGPRT1 No clinical guidelines available.
NegGram®(Nalidixic Acid) G6PD No clinical guidelines available.
Serzone® (Nefazodone) CYP2D6 No clinical guidelines available.
Tasigna®(Nilotinib) Ph Chromosome, UGT1A1 No clinical guidelines available.
Furadantin®(Nitrofurantoin) G6PD No clinical guidelines available.
Opdivo®(Nivolumab) BRAF, CD274 No clinical guidelines available.
Pamelor®(Nortriptyline) CYP2D6 CPIC Guidelines (2013)
Gazyva®(Obinutuzumab) MS4A1 No clinical guidelines available.
Viekira Pak®, Viekira XR®(Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir) IFNL3 No clinical guidelines available.
Synribo®(Omacetaxine) BCR/ABL1 No clinical guidelines available.
Tagrisso®(Osimertinib) EGFR No clinical guidelines available.
Ibrance®(Palbociclib) ERBB2, ESR1 No clinical guidelines available.
Aloxi®(Palonosetron) CYP2D6 No clinical guidelines available.
Prilosec®(Omeprazole) CYP2C19 No clinical guidelines available.
Vectibix®(Panitumumab) KRAS, EGFR National Comprehensive Cancer Network (2014)
Protonix®(Pantoprazole) CYP2C19 No clinical guidelines available.
Natpara®(Parathyroid Hormone) CASR No clinical guidelines available.
MoviPrep®(PEG-3350) G6PD No clinical guidelines available.
Paxil®(Paroxetine) CYP2D6 CPIC Guidelines (2015)
Votrient®(Pazopanib) UGT1A1 No clinical guidelines available.
Krystexxa®(Pegloticase) G6PD No clinical guidelines available.
Keytruda®(Pembrolizumab) BRAF, CD274 No clinical guidelines available.
Trilafon® (Perphenazine) CYP2D6 No clinical guidelines available.
Perjeta® (Pertuzumab) HER2/neu No clinical guidelines available.
Dilantin®(Phenytoin) CYP2C9, CYP2C19, HLA-B*1502 CPIC Guidelines (2014)
Orap®(Pimozide) CYP2D6 No clinical guidelines available.
Iclusig®(Ponatinib) BCR-ABLBCR/ABL1 No clinical guidelines available.
Effient®(Prasugrel) CYP2C9, CYP2B6, CYP3A5, CYP2C19 American College of Cardiology Foundation (2011)
Pravachol®(Pravastatin) ApoE2, LDLR No clinical guidelines available.
Oragix®, Prilolid®(Prilocaine and Lidocaine) CYB5R1-4, G6PD No clinical guidelines available.
Primaquine(Primaquine) G6PD No clinical guidelines available.
Rythmol SR®(Propafenone) CYP2D6 No clinical guidelines available.
Inderal®(Propranolol) CYP2D6 No clinical guidelines available.
Vivactil®(Protriptyline) CYP2D6 No clinical guidelines available.
Quinidine®(Quinidine) CYP2D6 No clinical guidelines available.
Qualaquin®(Quinine Sulfate) G6PD, CYP2D6 No clinical guidelines available.
Aciphex®(Rabeprazole) CYP2C19 No clinical guidelines available.
Elitek®(Rasburicase) G6PD, CYB5R1-4 CPIC Guidelines (2014)
Rifater®(Rifamipin, Isoniazid and Pyrazinamide) NAT1, NAT2 No clinical guidelines available.
Risperda®(Risperidone) CYP2D6 No clinical guidelines available.
Rituxan®(Rituximab) CD20 Antigen No clinical guidelines available.
Crestor®(Rosuvastatin) SLCO1B1, LDLR No clinical guidelines available.
Sojourn®, Ultane®(Sevoflurane) RYR1 No clinical guidelines available.
Olysio®(Simeprevir) IL28B No clinical guidelines available.
Zocor®(Simvastatin)
****Not in FDA Label
SLCO1B1 American College of Cardiology Foundation (2011)CPIC Guidelines (2014)
Sodium Nitrate(Sodium Nitrate) G6PD No clinical guidelines available.
Sodium Nitrate(Sodium Nitrate) G6PD No clinical guidelines available.
Ammonul®(Soduium phenylacetate and Sodium Benzoate) NAGS, CPS1, ASS1, OTC, ASL, ABL2 No clinical guidelines available.
Sovaldi®(Sofosbuvir) IL28B No clinical guidelines available.
Chemet®(Succimer) G6PD No clinical guidelines available.
Bactrim®(Sulfamethoxazole and Trimethoprim) G6PD No clinical guidelines available.
Nolvadex® (Tamoxifen) ER Receptor, Factor V Leiden carriers Prothrombin 20210A allele positive No clinical guidelines available.
Incivek®(Telaprevir) IL28B Dept of Veterans Affairs Hep C Resource Center Program and the National Hep C Program Office (2012)CPIC Guidelines (2014)
Xenazine®(Tetrabenazine) CYP2D6 No clinical guidelines available.
Tabloid®(Thioguanine) TPMT CPIC Guidelines (2013)
Mellaril® (Thioridazine) CYP2D6 No clinical guidelines available.
Brilinta®(Ticagrelor) CYP2C19 American College of Cardiology Foundation (2011)
Detrol® (Tolterodine) CYP2D6 No clinical guidelines available.
Bexxar®(Tositumomab) MS4A1 No clinical guidelines available.
Ultram®(Tramadol) CYP2D6 No clinical guidelines available.
Mekinist®(Trametinib) BRAF No clinical guidelines available.
Herceptin®(Trastuzumab) HER2/neu No clinical guidelines available.
Vesanoid®(Tretinoin) PML/RARα No clinical guidelines available.
Surmontil®(Trimipramine) CYP2D6 CPIC Guidelines (2013)
Stavzor®(Valproic Acid) POLG (NAGS,CPS,ASS,OTC,ASL,ARG) No clinical guidelines available.
Zelboraf®(Vemurafenib) BRAF, NRAS No clinical guidelines available.
Effexor®(Venlafaxine) CYP2D6 No clinical guidelines available.
Vfend®(Voriconazole) CYP2C9 No clinical guidelines available.
Brintellix®(Vortioxetine) CYP2D6 No clinical guidelines available.
Coumadin®(Warfarin) CYP2C9, VKORC1, Protein S deficiency, Protein C deficiency CPIC Guidelines (2011)American College of Chest Physicians (2008)

last updated February 17, 2017